Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 11/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 13/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.45 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.45 |
| ▸ | RAF1 | P04049 | 2/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.45 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.38 |
| ▸ | GCGR | P47871 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL69636 | 0.94 | BRAF (0.52) | BRAFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL67047 | 0.89 | BRAF (0.51) | BRAFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL67046 | 0.89 | BRAF (0.51) | BRAFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL69405 | 0.88 | BRAF (0.44) | BRAFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL69314 | 0.87 | BRAF (0.49) | BRAFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL68214 | 0.87 | BRAF (0.49) | BRAFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL68213 | 0.87 | BRAF (0.49) | BRAFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL66806 | 0.87 | BRAF (0.49) | BRAFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL66805 | 0.87 | BRAF (0.49) | BRAFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL68576 | 0.84 | BRAF (0.62) | BRAFMAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009115572-A2 | NOVEL HETEROCYCLIC COMPOUNDS AND USES THEROF | NOVARTIS AG (CH) | 2009-09-24 | — | — | WO | disclosed |