Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 17/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1367631 | 0.89 | MCHR1 (0.55) | MCHR1ALDH1A1HRH3 | |
| SCHEMBL15310239 | 0.85 | MCHR1 (0.73) | MCHR1 | |
| SCHEMBL1367127 | 0.81 | MCHR1 (0.52) | MCHR1MAPTMAPK1 | |
| SCHEMBL1365032 | 0.80 | MCHR1 (0.51) | MCHR1MAPTMAPK1 | |
| SCHEMBL4045053 | 0.78 | MCHR1 (0.64) | MCHR1 | |
| SCHEMBL2998090 | 0.77 | MCHR1 (0.47) | MCHR1CYP3A4CYP2D6CYP2C19HRH3 | |
| SCHEMBL15310316 | 0.77 | MCHR1 (0.62) | MCHR1 | |
| SCHEMBL15310200 | 0.77 | MCHR1 (0.62) | MCHR1 | |
| SCHEMBL15310293 | 0.76 | MCHR1 (0.64) | MCHR1 | |
| SCHEMBL15310276 | 0.75 | MCHR1 (0.65) | MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069327-B1 | NEW PYRIDONE DERIVATIVES WITH MCH ANTAGONISTIC ACTIVITY AND MEDICAMENTS COMPRISING THESE COMPOUNDS | BOEHRINGER INGELHEIM INT (DE) | 2013-10-16 | — | — | EP | claimed |
| US-8067590-B2 | Melanin-concentrating hormone (MCH) receptor antagonists; treating obesity, eating disorders, affective disorders, drug dependency; compounds are amino-functional pyridazin-3-one, 1H-pyridin-2-one or 3H-pyrimidin-4-one | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-11-29 | — | — | US | claimed |