Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 7/20 | 0.37 |
| ▸ | PADI4 | Q9UM07 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.35 |
| ▸ | ESR1 | P03372 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1366903 | 1.00 | DAO (0.40) | DAOBACE1PADI4ALOX15ESR1 | |
| SCHEMBL1366905 | 1.00 | DAO (0.40) | DAOBACE1PADI4ALOX15ESR1 | |
| SCHEMBL1368303 | 0.88 | DAO (0.46) | DAOBACE1PADI4ALOX15ESR1 | |
| SCHEMBL1366316 | 0.88 | DAO (0.46) | DAOBACE1PADI4ALOX15ESR1 | |
| SCHEMBL1366313 | 0.88 | DAO (0.46) | DAOBACE1PADI4ALOX15ESR1 | |
| SCHEMBL1366668 | 0.85 | BACE1 (0.45) | DAOBACE1 | |
| SCHEMBL1369129 | 0.85 | BACE1 (0.45) | DAOBACE1 | |
| SCHEMBL1366670 | 0.85 | BACE1 (0.45) | DAOBACE1 | |
| SCHEMBL1367272 | 0.82 | BACE1 (0.46) | DAOBACE1 | |
| SCHEMBL1367270 | 0.82 | BACE1 (0.46) | DAOBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090275650-A1 | 3-Acyl coumarins, thiochromones and quinolones and therapeutic uses thereof | TEMPLE UNIVERSITY- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2009-11-05 | — | — | US | claimed |
| WO-2006132947-A2 | 3-ACYL COUMARINS, THIOCHROMONES AND QUINOLONES AND THERAPEUTIC USES THEREOF | TEMPLE UNIVERSITY- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2006-12-14 | — | — | WO | claimed |
| US-8067461-B2 | 3-acyl coumarins, thiochromones and quinolones and therapeutic uses thereof | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2011-11-29 | — | — | US | disclosed |
| US-20090275650-A1 | 3-Acyl coumarins, thiochromones and quinolones and therapeutic uses thereof | TEMPLE UNIVERSITY- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2009-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275650-A1 | 3-Acyl coumarins, thiochromones and quinolones and therapeutic uses thereof | NQO2, NQO1, HCCS | DAO 3402/4885BACE1 4687/4885PADI4 3091/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.