Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 4/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.59 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | HTR2C | P28335 | 5/20 | 0.47 |
| ▸ | HTR2B | P41595 | 5/20 | 0.47 |
| ▸ | HTR2A | P28223 | 3/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.46 |
| ▸ | HTR3B | O95264 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.46 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL164537 | 1.00 | SLC6A2 (0.59) | SLC6A2SLC6A4SLC6A3CYP2D6HTR2C | |
| SCHEMBL5894706 | 0.98 | SLC6A2 (0.58) | SLC6A2SLC6A4SLC6A3CYP2D6HTR2C | |
| Methyl Alcohol SCHEMBL28137463 | 0.95 | SLC6A2 (0.55) | SLC6A2SLC6A4SLC6A3CYP2D6HTR2C | |
| SCHEMBL27587863 | 0.90 | SLC6A2 (0.57) | SLC6A2SLC6A4SLC6A3CYP2D6HTR2C | |
| SCHEMBL1945934 | 0.90 | SLC6A2 (0.50) | SLC6A2SLC6A4SLC6A3CYP2D6HTR2C | |
| SCHEMBL28597180 | 0.89 | SLC6A2 (0.52) | SLC6A2SLC6A4SLC6A3CYP2D6HTR2C | |
| Propanol SCHEMBL27627306 | 0.88 | SLC6A2 (0.50) | SLC6A2SLC6A4SLC6A3CYP2D6HTR2C | |
| Cyclohexanone SCHEMBL27571035 | 0.87 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3CYP2D6HTR2C | |
| SCHEMBL7998290 | 0.86 | SLC6A2 (0.50) | SLC6A2SLC6A4SLC6A3CYP2D6HTR2C | |
| SCHEMBL28597186 | 0.85 | SLC6A2 (0.50) | SLC6A2SLC6A4SLC6A3CYP2D6HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090221582-A1 | Piperazine Derivatives And Their Use In Therapy | VERNALIS (R&D) (GB) | 2009-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221582-A1 | Piperazine Derivatives And Their Use In Therapy | CNR2, CNR1, ALK | SLC6A2 275/4885SLC6A4 395/4885SLC6A3 135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.