Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.41 |
| ▸ | CYP3A5 | P20815 | 4/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MC4R | P32245 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | IDE | P14735 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 2/20 | 0.33 |
| ▸ | MDM4 | O15151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4154815 | 0.97 | CYP3A4 (0.39) | CYP3A4CYP3A5MDM2LMNAMAPK1 | |
| SCHEMBL13699551 | 0.97 | CYP3A4 (0.39) | CYP3A4CYP3A5MDM2LMNAMAPK1 | |
| SCHEMBL13699661 | 0.87 | MDM2 (0.40) | MDM2MC4RHTR2CCHRM2CHRM1 | |
| SCHEMBL4162064 | 0.86 | MDM2 (0.45) | CYP3A4CYP3A5MDM2LMNAMAPK1 | |
| SCHEMBL4162059 | 0.86 | MDM2 (0.45) | CYP3A4CYP3A5MDM2LMNAMAPK1 | |
| SCHEMBL13699636 | 0.84 | MDM2 (0.38) | MDM2MC4RHTR2CCHRM2CHRM1 | |
| SCHEMBL13699596 | 0.84 | MDM2 (0.44) | CYP3A4CYP3A5MDM2LMNAMAPK1 | |
| SCHEMBL13699631 | 0.83 | MDM2 (0.39) | CYP3A4CYP3A5MDM2LMNAMAPK1 | |
| SCHEMBL4163929 | 0.82 | MDM2 (0.42) | CYP3A4CYP3A5MDM2LMNAMAPK1 | |
| SCHEMBL13699615 | 0.82 | MDM2 (0.39) | CYP3A4CYP3A5MDM2LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090221582-A1 | Piperazine Derivatives And Their Use In Therapy | VERNALIS (R&D) (GB) | 2009-09-03 | — | — | US | disclosed |
| WO-2007057687-A1 | PIPERAZINE DERIVATIVES AND THEIR USE IN THERAPY | VERNALIS (R & D) LIMITED (GB) | 2007-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221582-A1 | Piperazine Derivatives And Their Use In Therapy | CNR2, CNR1, ALK | CYP3A4 1990/4885CYP3A5 1203/4885MDM2 2997/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.