Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 17/20 | 0.79 |
| ▸ | PDE4B | Q07343 | 17/20 | 0.79 |
| ▸ | PDE4C | Q08493 | 17/20 | 0.79 |
| ▸ | PDE4D | Q08499 | 17/20 | 0.79 |
| ▸ | TNF | P01375 | 4/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13699904 | 0.90 | PDE4A (0.64) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL6553133 | 0.89 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL31062863 | 0.88 | PDE4A (0.79) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL14528950 | 0.88 | TNF (0.64) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL2462406 | 0.86 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL8269361 | 0.85 | PDE4B (0.71) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL1566155 | 0.85 | PDE4B (0.81) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL2992015 | 0.85 | PDE4B (0.80) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL6555476 | 0.84 | PDE4B (0.80) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL8266749 | 0.84 | PDE4B (0.70) | PDE4APDE4BPDE4CPDE4DTNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090222080-A1 | MEDICAL STENT PROVIDED WITH INHIBITORS OF TUMOR NECROSIS FACTOR-ALPHA | PICARUS NV SA (LU) | 2009-09-03 | — | — | US | disclosed |