Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 3/20 | 0.56 |
| ▸ | TLR2 | O60603 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HTR2C | P28335 | 5/20 | 0.43 |
| ▸ | HTR2B | P41595 | 3/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17937228 | 0.95 | PRCP (0.61) | PRCPTLR2KDM4EHTR2CHTR2B | |
| Ethyne SCHEMBL45599 | 0.89 | PRCP (0.49) | PRCPTLR2KDM4EHTR2CHTR2B | |
| SCHEMBL18406520 | 0.82 | PRCP (0.48) | PRCPTLR2KDM4EHTR2CHTR2B | |
| SCHEMBL6360448 | 0.82 | PRCP (0.69) | PRCPTLR2KDM4EHTR2CHTR2B | |
| SCHEMBL6360674 | 0.82 | PRCP (0.69) | PRCPTLR2KDM4EHTR2CHTR2B | |
| SCHEMBL3969872 | 0.82 | PRCP (0.69) | PRCPTLR2KDM4EHTR2CHTR2B | |
| SCHEMBL24322424 | 0.81 | PRCP (0.59) | PRCPTLR2KDM4EHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL3268154 | 0.81 | PRCP (0.68) | PRCPTLR2KDM4EHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL6163226 | 0.81 | PRCP (0.68) | PRCPTLR2KDM4EHTR2CHTR2B | |
| SCHEMBL18412249 | 0.81 | PRCP (0.49) | PRCPTLR2KDM4EHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7589091-B2 | 2(R)-Benzyloxymethyl-4-[4-(4-chloro-phenyl)-piperazin-1-yl]-N-hydroxy-3(S)-(4-methoxy-phenyl)-4-oxo-butyramide; inhibiting matrix metalloproteinase; immunosuppression; neuropathic pain | NOVARTIS AG (CH) | 2009-09-15 | — | — | US | disclosed |
| US-7589091-B2 | 2(R)-Benzyloxymethyl-4-[4-(4-chloro-phenyl)-piperazin-1-yl]-N-hydroxy-3(S)-(4-methoxy-phenyl)-4-oxo-butyramide; inhibiting matrix metalloproteinase; immunosuppression; neuropathic pain | NOVARTIS AG (CH) | 2009-09-15 | — | — | US | disclosed |