Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.45 |
| ▸ | MAPT | P10636 | 7/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13709454 | 1.00 | MEN1 (0.45) | MEN1KMT2AMAPTRAB9ANPC1 | |
| SCHEMBL4432321 | 0.91 | MAPT (0.47) | MEN1KMT2AMAPTRAB9ANPC1 | |
| SCHEMBL4432235 | 0.91 | MAPT (0.47) | MEN1KMT2AMAPTRAB9ANPC1 | |
| SCHEMBL13600532 | 0.91 | MAPT (0.47) | MEN1KMT2AMAPTRAB9ANPC1 | |
| SCHEMBL4432231 | 0.91 | MAPT (0.47) | MEN1KMT2AMAPTRAB9ANPC1 | |
| SCHEMBL13600524 | 0.91 | MAPT (0.47) | MEN1KMT2AMAPTRAB9ANPC1 | |
| SCHEMBL14444840 | 0.90 | MEN1 (0.43) | MEN1KMT2AMAPTRAB9ANPC1 | |
| SCHEMBL14445496 | 0.90 | MEN1 (0.43) | MEN1KMT2AMAPTRAB9ANPC1 | |
| SCHEMBL4438269 | 0.76 | MAPT (0.47) | MEN1KMT2AMAPTRAB9ANPC1 | |
| SCHEMBL14300436 | 0.70 | MAPT (0.45) | MEN1KMT2AMAPTRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7592461-B2 | Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-09-22 | — | — | US | disclosed |