Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 12/20 | 0.74 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | PLAU | P00749 | 2/20 | 0.51 |
| ▸ | F2 | P00734 | 1/20 | 0.51 |
| ▸ | PLG | P00747 | 1/20 | 0.51 |
| ▸ | PLAT | P00750 | 1/20 | 0.51 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.51 |
| ▸ | KLK1 | P06870 | 1/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.51 |
| ▸ | SENP5 | Q96HI0 | 1/20 | 0.51 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.51 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.48 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13709530 | 0.90 | HDAC1 (0.74) | HDAC1NPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL7320266 | 0.87 | PLAU (0.65) | HDAC1NPC1RAB9APLAUF2 | |
| SCHEMBL1887309 | 0.85 | HDAC1 (1.00) | HDAC1SENP5SENP2SENP1 | |
| SCHEMBL13709559 | 0.84 | HDAC1 (0.54) | HDAC1NPC1RAB9APLAUF2 | |
| SCHEMBL13709593 | 0.84 | NPC1 (0.57) | HDAC1NPC1RAB9ASMN1; SMN2PLAU | |
| SCHEMBL13709594 | 0.83 | NPC1 (0.57) | HDAC1NPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL13709555 | 0.80 | HDAC1 (0.74) | HDAC1NPC1RAB9APLAUF2 | |
| SCHEMBL13709657 | 0.79 | F9 (0.50) | HDAC1NPC1RAB9AKMT2A | |
| SCHEMBL1892852 | 0.79 | HDAC1 (0.85) | HDAC1 | |
| SCHEMBL5566603 | 0.77 | PLAU (0.78) | NPC1RAB9APLAUF2PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090221564-A1 | Heterocyclic Compounds and Their Use in the Treatment of Cardiovascular Disease | TRIGEN LIMITED (GB) | 2009-09-03 | — | — | US | disclosed |
| US-20090221564-A1 | Heterocyclic Compounds and Their Use in the Treatment of Cardiovascular Disease | TRIGEN LIMITED (GB) | 2009-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221564-A1 | Heterocyclic Compounds and Their Use in the Treatment of Cardiovascular Disease | F12, F5, F3 | HDAC1 827/4885NPC1 3342/4885RAB9A 1135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.