Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.41 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13676016 | 0.88 | TRPV1 (0.59) | TRPV1ALDH1A1TSHRNPC1RAB9A | |
| SCHEMBL13676024 | 0.88 | TRPV1 (0.59) | TRPV1ALDH1A1TSHRNPC1RAB9A | |
| SCHEMBL13676276 | 0.87 | TRPV1 (0.58) | TRPV1ALDH1A1TSHRNPC1RAB9A | |
| SCHEMBL13676002 | 0.87 | TRPV1 (0.57) | TRPV1ALDH1A1TSHRNPC1RAB9A | |
| SCHEMBL13676032 | 0.87 | TRPV1 (0.57) | TRPV1ALDH1A1TSHRNPC1RAB9A | |
| SCHEMBL13676042 | 0.86 | TRPV1 (0.56) | TRPV1ALDH1A1TSHRNPC1RAB9A | |
| SCHEMBL13676143 | 0.86 | TRPV1 (0.56) | TRPV1ALDH1A1TSHRNPC1RAB9A | |
| SCHEMBL13676022 | 0.86 | TRPV1 (0.56) | TRPV1ALDH1A1TSHRNPC1RAB9A | |
| SCHEMBL13676035 | 0.84 | TRPV1 (0.55) | TRPV1ALDH1A1TSHRNPC1RAB9A | |
| SCHEMBL13676009 | 0.82 | TRPV1 (0.73) | TRPV1ALDH1A1TSHRNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582657-B2 | Treating inflammatory and neuropathic pain, headache, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, eye disorders, bladder disorders, psoriasis, skin disorders, asthma, herpes simplex | AMGEN INC. (US) | 2009-09-01 | — | — | US | disclosed |