Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SETD7 | Q8WTS6 | 5/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.48 |
| ▸ | DRD1 | P21728 | 5/20 | 0.48 |
| ▸ | HTR1A | P08908 | 4/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.48 |
| ▸ | DRD3 | P35462 | 4/20 | 0.48 |
| ▸ | HTR2A | P28223 | 4/20 | 0.48 |
| ▸ | HTR2C | P28335 | 4/20 | 0.48 |
| ▸ | HRH1 | P35367 | 4/20 | 0.48 |
| ▸ | HTR2B | P41595 | 4/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.48 |
| ▸ | DRD2 | P14416 | 3/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3131282 | 0.90 | SETD7 (0.57) | SETD7KCNH2CHRM2CHRM1ADRA1A | |
| SCHEMBL11600017 | 0.86 | SETD7 (0.71) | SETD7KCNH2CHRM2CHRM1ADRA1A | |
| SCHEMBL13712942 | 0.86 | SETD7 (0.56) | SETD7KCNH2CHRM2CHRM1ADRA1A | |
| SCHEMBL490214 | 0.86 | SETD7 (0.56) | SETD7KCNH2CHRM2CHRM1ADRA1A | |
| SCHEMBL11576524 | 0.86 | SETD7 (0.56) | SETD7KCNH2CHRM2CHRM1ADRA1A | |
| SCHEMBL3138524 | 0.83 | SETD7 (0.52) | SETD7KCNH2CHRM2CHRM1ADRA1A | |
| SCHEMBL490195 | 0.82 | SETD7 (0.51) | SETD7KCNH2CHRM2CHRM1ADRA1A | |
| SCHEMBL13870476 | 0.80 | SETD7 (0.58) | SETD7KCNH2CHRM2CHRM1ADRA1A | |
| SCHEMBL490196 | 0.79 | SETD7 (0.48) | SETD7KCNH2CHRM2CHRM1ADRA1A | |
| SCHEMBL14087482 | 0.79 | SETD7 (0.74) | SETD7KCNH2CHRM2CHRM1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7589103-B2 | Especially 2-aminocarbonyl-9-(thio)xanthenylidene-8-aza-bicyclo[3.2.1] octane derivatives are used in pharmaceutical and veterinary compositions for treating mild to severe pain and various diseases | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-09-15 | — | — | US | disclosed |