Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 20/20 | 0.86 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.78 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2876791 | 0.92 | CCR1 (1.00) | CCR1CYP2C19KCNH2 | |
| SCHEMBL2866562 | 0.88 | CCR1 (1.00) | CCR1CYP2C19KCNH2 | |
| SCHEMBL2866978 | 0.88 | CCR1 (1.00) | CCR1CYP2C19KCNH2 | |
| SCHEMBL2874768 | 0.85 | CCR1 (0.87) | CCR1CYP2C19KCNH2 | |
| SCHEMBL13162691 | 0.85 | CCR1 (0.93) | CCR1CYP2C19KCNH2 | |
| SCHEMBL2875774 | 0.84 | CCR1 (0.86) | CCR1CYP2C19KCNH2 | |
| SCHEMBL2875657 | 0.84 | CCR1 (0.82) | CCR1CYP2C19KCNH2 | |
| SCHEMBL2869925 | 0.84 | CCR1 (1.00) | CCR1CYP2C19KCNH2 | |
| SCHEMBL13066146 | 0.84 | CCR1 (0.78) | CCR1CYP2C19KCNH2 | |
| SCHEMBL2866838 | 0.83 | CCR1 (0.79) | CCR1CYP2C19KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1531822-B1 | 1-ARYL-4-SUBSTITUTED PIPERAZINE DERIVATIVES FOR USE AS CCR1 ANTAGONISTS FOR THE TREATMENT OF INFLAMMATION AND IMMUNE DISORDERS | CHEMOCENTRYX INC (US) | 2009-08-05 | — | — | EP | disclosed |