Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 10/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13066173 | 0.85 | CCR1 (0.49) | CCR1TSHRL3MBTL1TP53MAPT | |
| SCHEMBL13066172 | 0.84 | CCR1 (0.49) | CCR1TSHRLMNAMAPTHTT | |
| SCHEMBL14039675 | 0.82 | CCR1 (0.63) | CCR1TSHRL3MBTL1TP53LMNA | |
| SCHEMBL13715695 | 0.80 | CCR1 (0.52) | CCR1TSHRTP53LMNAMAPT | |
| SCHEMBL13066688 | 0.79 | CCR1 (0.71) | CCR1 | |
| SCHEMBL13715605 | 0.79 | CCR1 (0.48) | CCR1TSHRTP53LMNAMAPT | |
| SCHEMBL2873189 | 0.77 | CCR1 (0.59) | CCR1TSHRTP53LMNASMN1; SMN2 | |
| SCHEMBL2872952 | 0.74 | CCR1 (0.74) | CCR1TP53 | |
| SCHEMBL2873980 | 0.74 | CCR1 (0.64) | CCR1TP53LMNAMAPTTHRB | |
| SCHEMBL2870322 | 0.74 | CCR1 (0.64) | CCR1TP53LMNAMAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1531822-B1 | 1-ARYL-4-SUBSTITUTED PIPERAZINE DERIVATIVES FOR USE AS CCR1 ANTAGONISTS FOR THE TREATMENT OF INFLAMMATION AND IMMUNE DISORDERS | CHEMOCENTRYX INC (US) | 2009-08-05 | — | — | EP | disclosed |