Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 11/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.58 |
| ▸ | NCOR2 | Q9Y618 | 8/20 | 0.58 |
| ▸ | CRBN | Q96SW2 | 4/20 | 0.57 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.57 |
| ▸ | STAT3 | P40763 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | MIF | P14174 | 4/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2382454 | 1.00 | HDAC1 (0.58) | HDAC1HDAC3HDAC2NCOR2CRBN | |
| SCHEMBL30050518 | 0.91 | CRBN (0.66) | HDAC1HDAC3HDAC2NCOR2CRBN | |
| SCHEMBL30049440 | 0.91 | CRBN (0.66) | HDAC1HDAC3HDAC2NCOR2CRBN | |
| SCHEMBL23884287 | 0.89 | CRBN (0.65) | HDAC1HDAC3HDAC2NCOR2CRBN | |
| SCHEMBL2383505 | 0.88 | DDB1 (0.70) | HDAC1HDAC2CRBNDDB1STAT3 | |
| SCHEMBL26317743 | 0.87 | DDB1 (0.74) | HDAC1HDAC3HDAC2NCOR2CRBN | |
| SCHEMBL26323698 | 0.87 | DDB1 (0.74) | HDAC1HDAC3HDAC2NCOR2CRBN | |
| SCHEMBL26317747 | 0.87 | DDB1 (0.74) | HDAC1HDAC3HDAC2NCOR2CRBN | |
| SCHEMBL26317745 | 0.87 | DDB1 (0.74) | HDAC1HDAC3HDAC2NCOR2CRBN | |
| SCHEMBL22276611 | 0.87 | CRBN (0.75) | HDAC1HDAC3HDAC2NCOR2CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7576104-B2 | Isoindole-imide compounds, compositions, and uses thereof | CELGENE CORPORATION (US) | 2009-08-18 | — | — | US | disclosed |
| US-7576104-B2 | Isoindole-imide compounds, compositions, and uses thereof | CELGENE CORPORATION (US) | 2009-08-18 | — | — | US | disclosed |