Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | SCN1A | P35498 | 2/20 | 0.35 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL814598 | 0.92 | MAPT (0.48) | MAPTHTTHTR1AADRA1DADRA1A | |
| SCHEMBL814657 | 0.90 | MAPT (0.46) | MAPTHTTHTR1AADRA1DADRA1A | |
| SCHEMBL814427 | 0.90 | MAPT (0.46) | MAPTHTTHTR1AADRA1DADRA1A | |
| SCHEMBL816147 | 0.90 | MAPT (0.46) | MAPTHTTHTR1AADRA1DADRA1A | |
| SCHEMBL814335 | 0.90 | MAPT (0.46) | MAPTHTTHTR1AADRA1DADRA1A | |
| SCHEMBL814019 | 0.90 | MAPT (0.46) | MAPTHTTHTR1AADRA1DADRA1A | |
| Hydrochloric Acid SCHEMBL814618 | 0.88 | MAPT (0.45) | MAPTHTTHTR1AADRA1DADRA1A | |
| Hydrochloric Acid SCHEMBL812769 | 0.88 | MAPT (0.45) | MAPTHTTHTR1AADRA1DADRA1A | |
| Hydrochloric Acid SCHEMBL814366 | 0.88 | MAPT (0.45) | MAPTHTTHTR1AADRA1DADRA1A | |
| Hydrochloric Acid SCHEMBL813843 | 0.88 | MAPT (0.45) | MAPTHTTHTR1AADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1457488-B1 | Intermediates for use in the preparation of urea compounds having muscarinic receptor antagonist activity | THERAVANCE INC (US) | 2009-08-12 | — | — | EP | disclosed |