Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 20/20 | 0.86 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.86 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.86 |
| ▸ | CDK1 | P06493 | 1/20 | 0.86 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.86 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.86 |
| ▸ | PIM1 | P11309 | 1/20 | 0.86 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.86 |
| ▸ | PRKACA | P17612 | 1/20 | 0.86 |
| ▸ | CDK2 | P24941 | 1/20 | 0.86 |
| ▸ | MATK | P42679 | 1/20 | 0.86 |
| ▸ | FRK | P42685 | 1/20 | 0.86 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.86 |
| ▸ | CLK2 | P49760 | 1/20 | 0.86 |
| ▸ | GSK3A | P49840 | 1/20 | 0.86 |
| ▸ | GSK3B | P49841 | 1/20 | 0.86 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.86 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.86 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.86 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.86 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13671812 | 0.93 | PRKCQ (0.74) | PRKCQDCLK1MAP4K4CDK1CYP3A4 | |
| SCHEMBL1917079 | 0.93 | PRKCQ (1.00) | PRKCQDCLK1MAP4K4CDK1CYP3A4 | |
| SCHEMBL13794241 | 0.92 | PRKCQ (1.00) | PRKCQDCLK1MAP4K4CDK1CYP3A4 | |
| SCHEMBL13793849 | 0.92 | PRKCQ (1.00) | PRKCQDCLK1MAP4K4CDK1CYP3A4 | |
| SCHEMBL13719935 | 0.92 | PRKCQ (1.00) | PRKCQDCLK1MAP4K4CDK1CYP3A4 | |
| SCHEMBL13793832 | 0.90 | PRKCQ (1.00) | PRKCQDCLK1MAP4K4CDK1CYP3A4 | |
| SCHEMBL3832831 | 0.89 | PRKCQ (0.85) | PRKCQDCLK1MAP4K4CDK1CYP3A4 | |
| SCHEMBL13794257 | 0.88 | PRKCQ (1.00) | PRKCQDCLK1MAP4K4CDK1CYP3A4 | |
| SCHEMBL13794370 | 0.87 | PRKCQ (0.85) | PRKCQDCLK1MAP4K4CDK1CYP3A4 | |
| SCHEMBL13793864 | 0.87 | PRKCQ (1.00) | PRKCQDCLK1MAP4K4CDK1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3185858-A1 | COMPOSITIONS FOR MODULATING CANCER STEM CELLS AND USES THEREFOR | University of Canberra (AU) | 2017-07-05 | — | — | EP | disclosed |
| WO-2016029262-A1 | COMPOSITIONS FOR MODULATING CANCER STEM CELLS AND USES THEREFOR | UNIVERSITY OF CANBERRA (AU) | 2016-03-03 | — | — | WO | disclosed |
| EP-1590334-B1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF PKC-THETA | BOEHRINGER INGELHEIM PHARMA (US) | 2009-08-19 | — | — | EP | disclosed |
| US-7550473-B2 | Pyrimidine derivatives useful as inhibitors of PKC-theta | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-06-23 | — | — | US | disclosed |