Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 20/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.68 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.68 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.68 |
| ▸ | CDK1 | P06493 | 1/20 | 0.68 |
| ▸ | PIM1 | P11309 | 1/20 | 0.68 |
| ▸ | PRKACA | P17612 | 1/20 | 0.68 |
| ▸ | CDK2 | P24941 | 1/20 | 0.68 |
| ▸ | MATK | P42679 | 1/20 | 0.68 |
| ▸ | FRK | P42685 | 1/20 | 0.68 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.68 |
| ▸ | CLK2 | P49760 | 1/20 | 0.68 |
| ▸ | GSK3A | P49840 | 1/20 | 0.68 |
| ▸ | GSK3B | P49841 | 1/20 | 0.68 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.68 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.68 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.68 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3813448 | 0.93 | PRKCQ (1.00) | PRKCQCYP3A4CYP2C9CYP2D6DCLK1 | |
| Ammonia Solution, Strong SCHEMBL3820715 | 0.84 | PRKCQ (0.78) | PRKCQCYP3A4CYP2C9CYP2D6DCLK1 | |
| SCHEMBL6224553 | 0.83 | PRKCQ (0.71) | PRKCQCYP3A4CYP2C9CYP2D6DCLK1 | |
| SCHEMBL13719730 | 0.82 | PRKCQ (1.00) | PRKCQCYP3A4CYP2C9CYP2D6DCLK1 | |
| SCHEMBL3816094 | 0.82 | PRKCQ (1.00) | PRKCQCYP3A4CYP2C9CYP2D6DCLK1 | |
| SCHEMBL13794096 | 0.82 | PRKCQ (1.00) | PRKCQCYP3A4CYP2C9CYP2D6DCLK1 | |
| SCHEMBL1917079 | 0.81 | PRKCQ (1.00) | PRKCQCYP3A4CYP2C9CYP2D6DCLK1 | |
| SCHEMBL1916912 | 0.80 | STK17A (0.70) | PRKCQCYP3A4CYP2C9GSK3AGSK3B | |
| SCHEMBL13671753 | 0.78 | PRKCQ (0.87) | PRKCQCYP3A4CYP2C9CYP2D6DCLK1 | |
| SCHEMBL13793787 | 0.78 | PRKCQ (1.00) | PRKCQCYP3A4CYP2C9CYP2D6DCLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1590334-B1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF PKC-THETA | BOEHRINGER INGELHEIM PHARMA (US) | 2009-08-19 | — | — | EP | disclosed |
| US-7550473-B2 | Pyrimidine derivatives useful as inhibitors of PKC-theta | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-06-23 | — | — | US | disclosed |