Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | QRFPR | Q96P65 | 1/20 | 0.35 |
| ▸ | TPH1 | P17752 | 2/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | SLC6A7 | Q99884 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM6B | O15054 | 2/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.32 |
| ▸ | SLC6A15 | Q9H2J7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3810605 | 0.89 | GRM5 (0.40) | MCHR1GRM5DRD1QRFPRP2RX7 | |
| SCHEMBL3810568 | 0.87 | MEN1 (0.38) | MCHR1GRM5DRD1MEN1KMT2A | |
| SCHEMBL13720280 | 0.85 | KMT2A (0.38) | GRM5DRD1QRFPRMEN1KMT2A | |
| SCHEMBL3812746 | 0.84 | GRM5 (0.42) | GRM5DRD1QRFPRP2RX7 | |
| SCHEMBL3817993 | 0.83 | GRM5 (0.39) | MCHR1GRM5P2RX7PARP1MEN1 | |
| SCHEMBL3817657 | 0.82 | MCHR1 (0.40) | MCHR1GRM5DRD1QRFPRP2RX7 | |
| SCHEMBL3810414 | 0.82 | KMT2A (0.38) | GRM5MEN1KMT2A | |
| SCHEMBL3821199 | 0.81 | QRFPR (0.38) | DRD1QRFPRMEN1KMT2A | |
| SCHEMBL8012792 | 0.80 | DRD1 (0.49) | GRM5DRD1PARP1MEN1KMT2A | |
| SCHEMBL3812114 | 0.80 | DRD1 (0.49) | GRM5DRD1PARP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |