Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.46 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | CDK9 | P50750 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | PDE1A | P54750 | 1/20 | 0.37 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3985913 | 0.87 | HSP90AA1 (0.50) | HSP90AA1HSP90B1ALDH1A1NPSR1KMT2A | |
| SCHEMBL3978850 | 0.86 | HSP90AA1 (0.43) | HSP90AA1HSP90B1ALDH1A1NPSR1MAPT | |
| SCHEMBL3985958 | 0.86 | HSP90AA1 (0.44) | HSP90AA1HSP90B1ALDH1A1NPSR1KMT2A | |
| SCHEMBL3983750 | 0.84 | HSP90AA1 (0.43) | HSP90AA1HSP90B1ALDH1A1KMT2ANCOA1 | |
| SCHEMBL13720182 | 0.83 | HSP90AA1 (0.42) | HSP90AA1HSP90B1ALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL3977370 | 0.81 | HSP90AA1 (0.47) | HSP90AA1HSP90B1ALDH1A1KMT2AMEN1 | |
| SCHEMBL3978717 | 0.80 | HSP90AA1 (0.46) | HSP90AA1HSP90B1ALDH1A1POLBTHRB | |
| SCHEMBL3981174 | 0.80 | HSP90B1 (0.52) | HSP90AA1HSP90B1 | |
| SCHEMBL3980102 | 0.79 | HSP90AA1 (0.47) | HSP90AA1HSP90B1RAB9A | |
| SCHEMBL3979518 | 0.79 | HSP90AA1 (0.39) | HSP90AA1HSP90B1ALDH1A1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7572921-B2 | Substituted benzylimidazoles useful for the treatment of inflammatory diseases | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-08-11 | — | — | US | disclosed |