Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.58 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.58 |
| ▸ | ESR1 | P03372 | 1/20 | 0.57 |
| ▸ | PGR | P06401 | 1/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.57 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.57 |
| ▸ | DRD1 | P21728 | 1/20 | 0.57 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.57 |
| ▸ | PDE4A | P27815 | 1/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.57 |
| ▸ | DRD3 | P35462 | 1/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13890098 | 0.96 | KDM5A (0.62) | KDM5AKDM7AESR1PGRCHRM2 | |
| SCHEMBL2501228 | 0.92 | KDM5A (0.58) | KDM5AKDM7AESR1PGRCHRM2 | |
| SCHEMBL2040079 | 0.91 | ESR1 (0.59) | KDM5AKDM7AESR1PGRCHRM2 | |
| SCHEMBL282404 | 0.89 | ESR1 (0.72) | ESR1PGRCHRM2HTR1AADRA2A | |
| SCHEMBL9485915 | 0.89 | SIRT3 (0.60) | ESR1PGRCHRM2HTR1AADRA2A | |
| SCHEMBL14962957 | 0.89 | KDM5A (0.55) | KDM5AKDM7AESR1PGRCHRM2 | |
| SCHEMBL15426050 | 0.89 | ESR1 (0.62) | ESR1PGRCHRM2HTR1AADRA2A | |
| SCHEMBL31505225 | 0.89 | ESR1 (0.72) | ESR1PGRCHRM2HTR1AADRA2A | |
| SCHEMBL12822110 | 0.89 | SIRT3 (0.58) | ESR1PGRCHRM2HTR1AADRA2A | |
| SCHEMBL15409177 | 0.88 | KDM5A (0.55) | KDM5AKDM7AESR1PGRCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105315245-A | Benzofuran derivative, preparation method and application thereof | CHINA RESOURCES SAIKE PHARMACEUTICAL CO LTD | 2016-02-10 | — | — | CN | disclosed |
| US-8889734-B2 | Process for the preparation of dronedarone | SANOFI (FR) | 2014-11-18 | — | — | US | disclosed |
| US-20130261321-A1 | PROCESS FOR THE PREPARATION OF DRONEDARONE | SANOFI (FR) | 2013-10-03 | — | — | US | disclosed |
| US-8501971-B2 | Process for the preparation of dronedarone | SANOFI (FR) | 2013-08-06 | — | — | US | disclosed |
| US-20120289717-A1 | NEW PROCESS FOR THE PREPARATION OF DRONEDARONE | SANOFI (FR) | 2012-11-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120289717-A1 | NEW PROCESS FOR THE PREPARATION OF DRONEDARONE | CYP3A4, CYP4B1, CYP2D6 | KDM5A 1800/4885KDM7A 2370/4885ESR1 4507/4885 |
| US-20130261321-A1 | PROCESS FOR THE PREPARATION OF DRONEDARONE | CYP2D6, CYP3A4, CYP4B1 | KDM5A 1538/4885KDM7A 2252/4885ESR1 4472/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.