Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 18/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.44 |
| ▸ | BRAF | P15056 | 2/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3316070 | 0.77 | MAPK14 (0.52) | MAPK14MAPK11BRAFMAPK13MAPK12 | |
| SCHEMBL11965675 | 0.68 | MAPK14 (0.61) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL1417244 | 0.67 | MAPK14 (0.61) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL13523640 | 0.67 | MAPK14 (0.60) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL3316305 | 0.67 | MAPK14 (0.54) | MAPK14MAPK11BRAFMAPK13MAPK12 | |
| SCHEMBL10090803 | 0.67 | MAPK14 (0.70) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL12676759 | 0.66 | MAPK11 (0.65) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL3321105 | 0.65 | MAPK14 (0.52) | MAPK14MAPK11BRAFMAPK13MAPK12 | |
| SCHEMBL243562 | 0.65 | MAPK14 (0.60) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL243758 | 0.65 | MAPK11 (0.60) | MAPK14MAPK11MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1635824-B1 | 5-MEMBERED HETEROCYCLE-BASED P-38 INHIBITORS | NOVARTIS AG (CH) | 2009-08-19 | — | — | EP | disclosed |