SCHEMBL13722020

SCHEMBL13722020

CCCCc1nc2c(N)nc3c(c2n1CCCCNS(=O)(=O)Cc1ccccc1)CCCC3

nearest known ligand 0.48

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 20/20 0.48
TLR8 Q9NR97 10/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13721735 0.90 TLR7 (0.45) TLR7
SCHEMBL3819227 0.87 TLR7 (0.51) TLR7TLR8
SCHEMBL5750680 0.85 TLR7 (0.53) TLR7TLR8
SCHEMBL14516583 0.84 TLR7 (0.41) TLR7TLR8
SCHEMBL3820082 0.84 TLR7 (0.41) TLR7TLR8
SCHEMBL3976624 0.84 TLR7 (0.50) TLR7TLR8
SCHEMBL3831915 0.84 TLR7 (0.43) TLR7TLR8
SCHEMBL3815392 0.83 TLR7 (0.41) TLR7TLR8
SCHEMBL728453 0.83 TLR7 (0.70) TLR7TLR8
SCHEMBL5749146 0.83 TLR7 (0.45) TLR7TLR8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1642580-B1 Sulfonamide substituted imidazoquinolines COLEY PHARM GROUP INC (US) 2009-08-19 EP disclosed
US-7199131-B2 Sulfonamide and sulfamide substituted imidazoquinolines 3M INNOVATIVE PROPERTIES COMPANY (US) 2007-04-03 US disclosed
US-7199131-B2 Sulfonamide and sulfamide substituted imidazoquinolines 3M INNOVATIVE PROPERTIES COMPANY (US) 2007-04-03 US disclosed