Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 20/20 | 0.69 |
| ▸ | CCL2 | P13500 | 2/20 | 0.60 |
| ▸ | BRD2 | P25440 | 6/20 | 0.57 |
| ▸ | BRD3 | Q15059 | 5/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15450350 | 0.94 | BRD4 (0.69) | BRD4CCL2BRD2BRD3 | |
| SCHEMBL15437495 | 0.93 | BRD4 (0.68) | BRD4CCL2BRD2BRD3 | |
| SCHEMBL15437285 | 0.92 | BRD4 (0.67) | BRD4CCL2BRD2BRD3 | |
| SCHEMBL15437246 | 0.92 | BRD4 (0.66) | BRD4CCL2BRD2BRD3 | |
| SCHEMBL13722963 | 0.91 | BRD4 (0.63) | BRD4CCL2BRD2BRD3 | |
| SCHEMBL15437456 | 0.90 | BRD4 (0.75) | BRD4CCL2BRD2BRD3 | |
| SCHEMBL13723151 | 0.90 | BRD4 (0.68) | BRD4CCL2BRD2BRD3 | |
| SCHEMBL13724261 | 0.90 | BRD4 (0.63) | BRD4CCL2BRD2BRD3 | |
| SCHEMBL15437403 | 0.90 | BRD4 (0.65) | BRD4CCL2BRD2BRD3 | |
| SCHEMBL13727471 | 0.90 | BRD4 (0.65) | BRD4CCL2BRD2BRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3168213-B1 | TETRAHYDROQUINOLINE DERIVATIVES USEFUL AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2018-08-01 | — | — | EP | disclosed |
| EP-3168213-A1 | TETRAHYDROQUINOLINE DERIVATIVES USEFUL AS BROMODOMAIN INHIBITORS | Glaxosmithkline LLC (US) | 2017-05-17 | — | — | EP | disclosed |
| EP-2699551-B1 | TETRAHYDROQUINOLINE DERIVATIVES USEFUL AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2016-11-16 | — | — | EP | disclosed |
| US-8993554-B2 | Tetrahydroquinoline derivatives useful as bromodomain inhibitors | GLAXOSMITHKLINE LLC (US) | 2015-03-31 | — | — | US | disclosed |
| EP-2699551-A1 | TETRAHYDROQUINOLINE DERIVATIVES USEFUL AS BROMODOMAIN INHIBITORS | Glaxosmithkline LLC (US) | 2014-02-26 | — | — | EP | disclosed |
| US-20140031336-A1 | Tetrahydroquinoline Derivatives Useful As Bromodomain Inhibitors | GLAXOSMITHKLINE LLC (US) | 2014-01-30 | — | — | US | disclosed |
| WO-2012143415-A1 | TETRAHYDROQUINOLINE DERIVATIVES USEFUL AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2012-10-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140031336-A1 | Tetrahydroquinoline Derivatives Useful As Bromodomain Inhibitors | BRD4, BRDT, BRD3 | BRD4 1/4885CCL2 1857/4885BRD2 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.