Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 6/20 | 0.60 |
| ▸ | NTRK1 | P04629 | 6/20 | 0.50 |
| ▸ | NTRK3 | Q16288 | 5/20 | 0.50 |
| ▸ | NTRK2 | Q16620 | 4/20 | 0.50 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 8/20 | 0.41 |
| ▸ | INSR | P06213 | 7/20 | 0.41 |
| ▸ | PRKCB | P05771 | 2/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | PRKCG | P05129 | 1/20 | 0.41 |
| ▸ | ROS1 | P08922 | 1/20 | 0.41 |
| ▸ | FER | P16591 | 1/20 | 0.41 |
| ▸ | LTK | P29376 | 1/20 | 0.41 |
| ▸ | WEE1 | P30291 | 1/20 | 0.41 |
| ▸ | FRK | P42685 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MST1R | Q04912 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1892157 | 0.90 | IGF1R (0.58) | IGF1RNTRK1NTRK3NTRK2ALK | |
| SCHEMBL1370806 | 0.89 | IGF1R (0.61) | IGF1RNTRK1NTRK3NTRK2CCNA2 | |
| SCHEMBL4282762 | 0.89 | IGF1R (0.64) | IGF1RNTRK1NTRK3NTRK2CCNA2 | |
| SCHEMBL1370668 | 0.89 | IGF1R (0.60) | IGF1RNTRK1NTRK3NTRK2CCNA2 | |
| SCHEMBL1370834 | 0.89 | IGF1R (0.66) | IGF1RNTRK1NTRK3NTRK2CCNA2 | |
| SCHEMBL1372669 | 0.88 | IGF1R (0.61) | IGF1RNTRK1NTRK3NTRK2CCNA2 | |
| SCHEMBL1370964 | 0.88 | IGF1R (0.65) | IGF1RNTRK1NTRK3NTRK2CCNA2 | |
| SCHEMBL1373927 | 0.88 | IGF1R (0.61) | IGF1RNTRK1NTRK3NTRK2CCNA2 | |
| SCHEMBL1372012 | 0.88 | IGF1R (0.66) | IGF1RNTRK1NTRK3NTRK2CCNA2 | |
| SCHEMBL1374840 | 0.87 | IGF1R (0.60) | IGF1RNTRK1NTRK3NTRK2CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110288088-A1 | SUBSTITUTED PYRROLO-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.I. (IT) | 2011-11-24 | — | — | US | disclosed |
| US-7968583-B2 | Substituted pyrrolo-pyrazole derivatives active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110288088-A1 | SUBSTITUTED PYRROLO-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | MAP3K5, MAP3K19, MAP3K3 | IGF1R 737/4885NTRK1 1363/4885NTRK3 1220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.