Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 11/20 | 0.41 |
| ▸ | HTR2A | P28223 | 7/20 | 0.34 |
| ▸ | HTR2C | P28335 | 7/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13733303 | 1.00 | AR (0.41) | ARHTR2AHTR2CCYP1A2CYP3A4 | |
| SCHEMBL1817139 | 0.82 | AR (0.44) | ARHTR2AHTR2C | |
| SCHEMBL1817136 | 0.82 | AR (0.44) | ARHTR2AHTR2C | |
| SCHEMBL1815435 | 0.81 | AR (0.52) | ARHTR2AHTR2CLTA4HKCNH2 | |
| SCHEMBL1818302 | 0.81 | AR (0.52) | ARHTR2AHTR2CLTA4HKCNH2 | |
| SCHEMBL1815432 | 0.81 | AR (0.52) | ARHTR2AHTR2CLTA4HKCNH2 | |
| SCHEMBL1811872 | 0.81 | AR (0.58) | ARHTR2AHTR2CLTA4HKCNH2 | |
| SCHEMBL12079911 | 0.81 | AR (0.58) | ARHTR2AHTR2CLTA4HKCNH2 | |
| SCHEMBL1811871 | 0.81 | AR (0.58) | ARHTR2AHTR2CLTA4HKCNH2 | |
| SCHEMBL1817038 | 0.76 | AR (0.48) | AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2699561-B1 | ANDROGEN RECEPTOR MODULATING CARBOXAMIDES | ORION CORP (FI) | 2015-06-03 | — | — | EP | disclosed |
| US-8921378-B2 | Androgen receptor modulating carboxamides | ORION CORPORATION (FI) | 2014-12-30 | — | — | US | disclosed |
| EP-2699561-A1 | ANDROGEN RECEPTOR MODULATING CARBOXAMIDES | Orion Corporation (FI) | 2014-02-26 | — | — | EP | disclosed |
| WO-2012143599-A1 | ANDROGEN RECEPTOR MODULATING CARBOXAMIDES | ORION CORPORATION (FI) | 2012-10-26 | — | — | WO | disclosed |