Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 11/20 | 0.81 |
| ▸ | MEN1 | O00255 | 3/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.80 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.80 |
| ▸ | USP2 | O75604 | 2/20 | 0.80 |
| ▸ | HTT | P42858 | 2/20 | 0.80 |
| ▸ | NPC1 | O15118 | 2/20 | 0.80 |
| ▸ | POLB | P06746 | 1/20 | 0.80 |
| ▸ | RECQL | P46063 | 1/20 | 0.80 |
| ▸ | RAB9A | P51151 | 1/20 | 0.80 |
| ▸ | BLM | P54132 | 1/20 | 0.80 |
| ▸ | ATM | Q13315 | 1/20 | 0.70 |
| ▸ | UHRF1 | Q96T88 | 2/20 | 0.66 |
| ▸ | MYC | P01106 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | RAD52 | P43351 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13736177 | 0.92 | APEX1 (0.80) | APEX1MEN1KMT2AKDM4EUSP2 | |
| SCHEMBL1494905 | 0.90 | APEX1 (1.00) | APEX1MEN1KMT2AKDM4EUSP2 | |
| SCHEMBL13735656 | 0.88 | APEX1 (0.83) | APEX1MEN1KMT2AKDM4EUSP2 | |
| SCHEMBL13832373 | 0.87 | APEX1 (1.00) | APEX1MEN1KMT2AKDM4EUSP2 | |
| SCHEMBL23528082 | 0.86 | APEX1 (0.80) | APEX1MEN1KMT2AKDM4EUSP2 | |
| SCHEMBL18285885 | 0.86 | APEX1 (0.80) | APEX1MEN1KMT2AKDM4EUSP2 | |
| SCHEMBL13832370 | 0.86 | APEX1 (0.92) | APEX1MEN1KMT2AKDM4EUSP2 | |
| SCHEMBL18285943 | 0.86 | APEX1 (0.78) | APEX1MEN1KMT2AKDM4EUSP2 | |
| SCHEMBL18285877 | 0.85 | APEX1 (0.80) | APEX1MEN1KMT2AKDM4EUSP2 | |
| SCHEMBL13735474 | 0.85 | APEX1 (1.00) | APEX1MEN1KMT2AKDM4EUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012148889-A1 | INHIBITORS OF HUMAN APURINIC/APYRIMIDINIC ENDONUCLEASE 1 | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2012-11-01 | — | — | WO | disclosed |
| WO-2012148889-A1 | INHIBITORS OF HUMAN APURINIC/APYRIMIDINIC ENDONUCLEASE 1 | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2012-11-01 | — | — | WO | disclosed |