Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 20/20 | 0.73 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.52 |
| ▸ | FYN | P06241 | 1/20 | 0.52 |
| ▸ | FGR | P09769 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
| ▸ | FER | P16591 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.52 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.52 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.52 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13740416 | 0.87 | SYK (0.81) | SYKJAK2NTRK1FYNFGR | |
| SCHEMBL2509056 | 0.84 | SYK (0.63) | SYKJAK2NTRK1FYNFGR | |
| SCHEMBL13896070 | 0.84 | SYK (1.00) | SYK | |
| SCHEMBL13737790 | 0.84 | SYK (1.00) | SYK | |
| SCHEMBL13737093 | 0.84 | SYK (1.00) | SYKJAK2NTRK1FYNFGR | |
| SCHEMBL13896101 | 0.84 | SYK (1.00) | SYKJAK2NTRK1FYNFGR | |
| SCHEMBL13896100 | 0.84 | SYK (1.00) | SYKJAK2NTRK1FYNFGR | |
| SCHEMBL15733069 | 0.84 | SYK (1.00) | SYKJAK2NTRK1FYNFGR | |
| SCHEMBL13737067 | 0.84 | SYK (0.81) | SYK | |
| SCHEMBL13736719 | 0.82 | SYK (1.00) | SYKJAK2NTRK1FYNFGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2706853-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2014-03-19 | — | — | EP | disclosed |
| WO-2012154519-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-11-15 | — | — | WO | disclosed |