SCHEMBL13737844

SCHEMBL13737844

COc1ccc(COCCOc2ccc3c(NC(=O)c4ccccc4N4CCN(C)CC4)n[nH]c3c2)cc1

nearest known ligand 0.76

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
KIT P10721 20/20 0.76
FLT3 P36888 9/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13735924 0.95 KIT (0.78) KITFLT3
SCHEMBL13737900 0.87 KIT (0.79) KITFLT3
SCHEMBL13737976 0.87 KIT (0.85) KITFLT3
SCHEMBL13737640 0.86 KIT (1.00) KITFLT3
SCHEMBL13739346 0.84 KIT (0.79) KITFLT3
SCHEMBL13735846 0.82 KIT (1.00) KITFLT3
SCHEMBL13735916 0.82 KIT (1.00) KITFLT3
SCHEMBL13738056 0.81 KIT (1.00) KITFLT3
Hydrochloric Acid SCHEMBL13736574 0.80 KIT (0.98) KITFLT3
SCHEMBL18171381 0.80 KIT (1.00) KITFLT3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2707359-B1 SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES SRL (IT) 2016-11-30 EP claimed
EP-2707359-A1 SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS Nerviano Medical Sciences S.r.l. (IT) 2014-03-19 EP disclosed
WO-2012152763-A1 SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2012-11-15 WO disclosed