Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CCR5 | P51681 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PDE2A | O00408 | 12/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 12/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.41 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | PDE6D | O43924 | 2/20 | 0.39 |
| ▸ | PDE6A | P16499 | 2/20 | 0.39 |
| ▸ | PDE6G | P18545 | 2/20 | 0.39 |
| ▸ | PDE6B | P35913 | 2/20 | 0.39 |
| ▸ | PDE6C | P51160 | 2/20 | 0.39 |
| ▸ | PDE6H | Q13956 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13737280 | 0.80 | MEN1 (0.43) | CCR1RAB9ACCR5MEN1KMT2A | |
| SCHEMBL13740119 | 0.80 | PDE2A (0.45) | CCR1RAB9ACCR5MEN1KMT2A | |
| SCHEMBL13737998 | 0.79 | MEN1 (0.46) | CCR1RAB9ACCR5MEN1KMT2A | |
| SCHEMBL6088636 | 0.78 | CCR1 (0.52) | CCR1RAB9ACCR5MEN1KMT2A | |
| SCHEMBL12404220 | 0.78 | CCR1 (0.52) | CCR1RAB9ACCR5MEN1KMT2A | |
| SCHEMBL729287 | 0.78 | MEN1 (0.41) | CCR1RAB9ACCR5MEN1KMT2A | |
| SCHEMBL13739948 | 0.78 | CCR1 (0.48) | CCR1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL13737688 | 0.77 | CCR1 (0.52) | CCR1RAB9ACCR5MEN1KMT2A | |
| SCHEMBL16533363 | 0.76 | CA12 (0.50) | RAB9AMEN1KMT2A | |
| SCHEMBL15400315 | 0.76 | MCHR1 (0.49) | CCR1RAB9ACCR5MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2678329-B1 | TRIAZOLOPYRIDINE COMPOUNDS AS PIM KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2015-11-18 | — | — | EP | disclosed |
| US-8889704-B2 | Triazolopyridine compounds as PIM kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2014-11-18 | — | — | US | disclosed |
| US-20140005213-A1 | TRIAZOLOPYRIDINE COMPOUNDS AS PIM KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2014-01-02 | — | — | US | disclosed |
| EP-2678329-A1 | TRIAZOLOPYRIDINE COMPOUNDS AS PIM KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2014-01-01 | — | — | EP | disclosed |
| WO-2012154274-A1 | TRIAZOLOPYRIDINE COMPOUNDS AS PIM KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2012-11-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140005213-A1 | TRIAZOLOPYRIDINE COMPOUNDS AS PIM KINASE INHIBITORS | PIM1, PIM2, PIM3 | CCR1 3163/4885RAB9A 3116/4885CCR5 2747/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.