Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 3/20 | 0.39 |
| ▸ | RARG | P13631 | 2/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.38 |
| ▸ | BAD | Q92934 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.37 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.36 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | RARA | P10276 | 1/20 | 0.36 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 3/20 | 0.36 |
| ▸ | RXRB | P28702 | 3/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13831071 | 0.96 | RARB (0.41) | RARBRARGPTPN11SRD5A2CYP26A1 | |
| SCHEMBL13738163 | 0.86 | RARB (0.39) | RARBRARGPTPN11SRD5A2CYP26A1 | |
| SCHEMBL13831258 | 0.86 | RARB (0.39) | RARBRARGPTPN11SRD5A2CYP26A1 | |
| SCHEMBL13737615 | 0.86 | RARB (0.39) | RARBRARGPTPN11SRD5A2CYP26A1 | |
| SCHEMBL31303687 | 0.86 | RARB (0.39) | RARBRARGPTPN11SRD5A2CYP26A1 | |
| SCHEMBL17451854 | 0.86 | RARB (0.39) | RARBRARGPTPN11SRD5A2CYP26A1 | |
| SCHEMBL31303689 | 0.86 | RARB (0.39) | RARBRARGPTPN11SRD5A2CYP26A1 | |
| SCHEMBL13738717 | 0.86 | RARB (0.39) | RARBRARGPTPN11SRD5A2CYP26A1 | |
| SCHEMBL13741117 | 0.84 | PTPN11 (0.42) | PTPN11EGFR | |
| SCHEMBL17435680 | 0.82 | RARB (0.43) | RARBRARGCYP26A1CYP3A4RARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2638006-A1 | HYDROXAMIC ACID DERIVATIVES AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTIONS | Achaogen, Inc. (US) | 2013-09-18 | — | — | EP | disclosed |
| WO-2012154204-A1 | HYDROXAMIC ACID DERIVATIVES AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTIONS | ACHAOGEN, INC. (US) | 2012-11-15 | — | — | WO | disclosed |