Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 1/20 | 0.59 |
| ▸ | CDK2 | P24941 | 1/20 | 0.59 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.59 |
| ▸ | MAPK8 | P45983 | 12/20 | 0.58 |
| ▸ | SYK | P43405 | 8/20 | 0.58 |
| ▸ | MAPK9 | P45984 | 7/20 | 0.57 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.56 |
| ▸ | RET | P07949 | 2/20 | 0.56 |
| ▸ | JAK1 | P23458 | 2/20 | 0.56 |
| ▸ | TYK2 | P29597 | 2/20 | 0.56 |
| ▸ | FLT3 | P36888 | 2/20 | 0.56 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.56 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.56 |
| ▸ | STK4 | Q13043 | 2/20 | 0.56 |
| ▸ | STK3 | Q13188 | 2/20 | 0.56 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.56 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.56 |
| ▸ | RPS6KA6 | Q9UK32 | 2/20 | 0.56 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1355336 | 0.85 | SYK (0.71) | MAPK8SYKMAPK9 | |
| SCHEMBL17076551 | 0.84 | SYK (0.78) | MAPK8SYKMAPK9CHEK1RET | |
| SCHEMBL14658760 | 0.83 | SYK (0.66) | MAPK8SYKMAPK9JAK1FLT3 | |
| SCHEMBL14658762 | 0.83 | SYK (0.66) | MAPK8SYKMAPK9JAK1FLT3 | |
| SCHEMBL14659080 | 0.83 | SYK (0.66) | MAPK8SYKMAPK9JAK1FLT3 | |
| SCHEMBL14667124 | 0.83 | SYK (0.66) | MAPK8SYKMAPK9JAK1FLT3 | |
| SCHEMBL14659085 | 0.83 | SYK (0.66) | MAPK8SYKMAPK9JAK1FLT3 | |
| SCHEMBL14657253 | 0.82 | SYK (0.66) | MAPK8SYKMAPK9JAK1JAK2 | |
| SCHEMBL20920639 | 0.82 | MAPK8 (0.67) | MAPK8SYKMAPK9 | |
| SCHEMBL14658637 | 0.81 | MAPK8 (0.82) | MAPK8SYKMAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2699553-A1 | SUBSTITUTED DIAMINOCARBOXAMIDE AND DIAMINOCARBONITRILE PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | Signal Pharmaceuticals, LLC (US) | 2014-02-26 | — | — | EP | disclosed |
| WO-2012145569-A1 | SUBSTITUTED DIAMINOCARBOXAMIDE AND DIAMINOCARBONITRILE PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARMACEUTICALS, LLC (US) | 2012-10-26 | — | — | WO | disclosed |