Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 18/20 | 0.54 |
| ▸ | ACE | P12821 | 1/20 | 0.47 |
| ▸ | MMEL1 | Q495T6 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11969353 | 1.00 | MME (0.54) | MMEACEMMEL1 | |
| SCHEMBL11969407 | 1.00 | MME (0.54) | MMEACEMMEL1 | |
| SCHEMBL11969623 | 0.91 | MME (0.59) | MMEACEMMEL1 | |
| SCHEMBL11969630 | 0.91 | MME (0.59) | MMEACEMMEL1 | |
| SCHEMBL11969536 | 0.89 | MME (0.47) | MMEACEMMEL1 | |
| SCHEMBL11970038 | 0.88 | MME (0.69) | MMEACE | |
| SCHEMBL12480836 | 0.88 | MME (0.69) | MMEACE | |
| SCHEMBL19875312 | 0.88 | MME (0.69) | MMEACE | |
| SCHEMBL11969569 | 0.88 | MME (0.69) | MMEACE | |
| SCHEMBL12480732 | 0.88 | MME (0.69) | MMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675792-A1 | SUBSTITUTED AMINOBUTYRIC DERIVATIVES AS NEPRILYSIN INHIBITORS | Theravance, Inc. (US) | 2013-12-25 | — | — | EP | disclosed |
| WO-2012154249-A1 | SUBSTITUTED AMINOBUTYRIC DERIVATIVES AS NEPRILYSIN INHIBITORS | THERAVANCE, INC. (US) | 2012-11-15 | — | — | WO | disclosed |