Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TKT | P29401 | 17/20 | 0.60 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13741439 | 0.76 | TKT (0.55) | TKTHSP90AA1 | |
| SCHEMBL13741150 | 0.76 | TKT (0.69) | TKTHSP90AA1 | |
| SCHEMBL13741708 | 0.75 | TKT (1.00) | TKTHSP90AA1 | |
| SCHEMBL4029542 | 0.74 | TKT (0.30) | TKT | |
| SCHEMBL13741511 | 0.72 | TKT (0.69) | TKTHSP90AA1 | |
| Bromide SCHEMBL3844686 | 0.72 | TKT (0.50) | TKTHSP90AA1 | |
| SCHEMBL2900332 | 0.71 | TKT (0.61) | TKTHSP90AA1 | |
| Hydrochloric Acid SCHEMBL648277 | 0.70 | TKT (0.70) | TKTHSP90AA1 | |
| SCHEMBL6936412 | 0.70 | TKT (0.56) | TKTHSP90AA1 | |
| Hydrochloric Acid SCHEMBL29995247 | 0.70 | TKT (0.60) | TKTHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090209554-A1 | Thiazoliums as transketolase inhibitors | ARRAY BIOPHARMA INC. (US) | 2009-08-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090209554-A1 | Thiazoliums as transketolase inhibitors | TKT, RRM2, TYMS | TKT 1/4885HSP90AA1 3622/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.