Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 10/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2084518 | 0.92 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DPTGS2 | |
| SCHEMBL2084999 | 0.75 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DPTGS2 | |
| SCHEMBL2085195 | 0.75 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DALOX5 | |
| SCHEMBL2084878 | 0.74 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DALOX5 | |
| SCHEMBL2082824 | 0.74 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4DPTGS2 | |
| SCHEMBL2085307 | 0.73 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DALOX5 | |
| SCHEMBL2085857 | 0.73 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DPTGS2 | |
| SCHEMBL2083727 | 0.73 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DPTGS2 | |
| SCHEMBL2083722 | 0.72 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4DPTGS2 | |
| SCHEMBL2084336 | 0.72 | PDE4A (0.88) | PDE4APDE4BPDE4CPDE4DPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095773-A2 | NOVEL HETEROCYCLES | ORCHID RESEARCH LABORATORIES LIMITED (IN) | 2009-08-06 | — | — | WO | disclosed |