Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 5/20 | 0.42 |
| ▸ | CDK2 | P24941 | 5/20 | 0.42 |
| ▸ | FLT3 | P36888 | 5/20 | 0.42 |
| ▸ | TYK2 | P29597 | 6/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | TTK | P33981 | 1/20 | 0.38 |
| ▸ | VNN1 | O95497 | 1/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.37 |
| ▸ | PRKCA | P17252 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3667229 | 0.90 | CCNE1 (0.46) | CCNE1CDK2FLT3TYK2HDAC1 | |
| SCHEMBL3667232 | 0.90 | CCNE1 (0.46) | CCNE1CDK2FLT3TYK2HDAC1 | |
| SCHEMBL3722139 | 0.88 | CCNE1 (0.43) | CCNE1CDK2FLT3TYK2PRKCA | |
| SCHEMBL3720234 | 0.87 | TYK2 (0.46) | CCNE1CDK2FLT3TYK2TTK | |
| SCHEMBL3720223 | 0.87 | TYK2 (0.46) | CCNE1CDK2FLT3TYK2TTK | |
| SCHEMBL3721600 | 0.86 | CCNE1 (0.38) | CCNE1CDK2FLT3TYK2HDAC1 | |
| SCHEMBL3720201 | 0.86 | CCNE1 (0.38) | CCNE1CDK2FLT3TYK2HDAC1 | |
| SCHEMBL3775476 | 0.86 | TYK2 (0.55) | CCNE1CDK2FLT3TYK2 | |
| SCHEMBL3769510 | 0.86 | TYK2 (0.55) | CCNE1CDK2FLT3TYK2 | |
| SCHEMBL3769496 | 0.86 | TYK2 (0.55) | CCNE1CDK2FLT3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009100375-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-08-13 | — | — | WO | disclosed |