Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 12/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.37 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.37 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3731587 | 0.90 | TYK2 (0.53) | TYK2NTRK1PDE4DSTAT3 | |
| SCHEMBL13013308 | 0.90 | TYK2 (0.53) | TYK2NTRK1PDE4DSTAT3 | |
| SCHEMBL3731596 | 0.90 | TYK2 (0.53) | TYK2NTRK1PDE4DSTAT3 | |
| SCHEMBL3729262 | 0.84 | TYK2 (0.47) | TYK2PDE4DJAK2JAK1 | |
| SCHEMBL3729263 | 0.84 | TYK2 (0.47) | TYK2PDE4DJAK2JAK1 | |
| SCHEMBL13013392 | 0.84 | TYK2 (0.55) | TYK2PDE4DSTAT3 | |
| SCHEMBL3721108 | 0.84 | TYK2 (0.55) | TYK2PDE4DSTAT3 | |
| SCHEMBL3721100 | 0.84 | TYK2 (0.55) | TYK2PDE4DSTAT3 | |
| SCHEMBL3726040 | 0.83 | TYK2 (0.46) | TYK2PDE4D | |
| SCHEMBL3726041 | 0.83 | TYK2 (0.46) | TYK2PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009100375-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-08-13 | — | — | WO | disclosed |