Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 3/20 | 0.50 |
| ▸ | SYK | P43405 | 11/20 | 0.48 |
| ▸ | IP6K1 | Q92551 | 3/20 | 0.42 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | WEE1 | P30291 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1059320 | 0.93 | ZAP70 (0.59) | ZAP70SYKJAK2MAPTMAPK1 | |
| SCHEMBL1059382 | 0.89 | ZAP70 (0.55) | ZAP70SYKJAK2MAPTMAPK1 | |
| SCHEMBL1053661 | 0.84 | ZAP70 (0.61) | ZAP70SYKJAK2GAAMAPT | |
| SCHEMBL1056409 | 0.84 | SYK (0.56) | ZAP70SYKJAK2 | |
| SCHEMBL13745794 | 0.83 | ZAP70 (0.51) | ZAP70SYKIP6K1IP6K3JAK2 | |
| SCHEMBL1053031 | 0.83 | ZAP70 (0.59) | ZAP70SYKJAK2 | |
| SCHEMBL1058392 | 0.81 | ZAP70 (0.75) | ZAP70SYKJAK2GAAMAPT | |
| SCHEMBL13745880 | 0.81 | SYK (0.61) | ZAP70SYKIP6K1IP6K3JAK2 | |
| SCHEMBL1060495 | 0.80 | ZAP70 (0.62) | ZAP70SYKJAK2GAAMAPT | |
| SCHEMBL1058391 | 0.79 | SYK (0.69) | ZAP70SYKJAK2MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009099801-A1 | PYRIDO [4, 3-D] PYRIMIDINONE DERIVATIVES AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-13 | — | — | WO | disclosed |