Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 13/20 | 0.67 |
| ▸ | JAK2 | O60674 | 9/20 | 0.67 |
| ▸ | ZAP70 | P43403 | 9/20 | 0.67 |
| ▸ | LYN | P07948 | 8/20 | 0.67 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.44 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.41 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.41 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1053859 | 0.91 | SYK (0.71) | SYKJAK2ZAP70LYNRET | |
| SCHEMBL1053640 | 0.91 | SYK (0.67) | SYKJAK2ZAP70LYNRET | |
| SCHEMBL3403293 | 0.90 | SYK (0.64) | SYKJAK2ZAP70LYNRET | |
| SCHEMBL1060374 | 0.89 | SYK (0.63) | SYKJAK2ZAP70LYNRET | |
| SCHEMBL1051535 | 0.87 | SYK (0.65) | SYKJAK2ZAP70LYNRET | |
| SCHEMBL1053445 | 0.86 | SYK (0.60) | SYKJAK2ZAP70LYNFLT3 | |
| SCHEMBL1053861 | 0.86 | SYK (0.60) | SYKJAK2ZAP70LYNFLT3 | |
| SCHEMBL1056396 | 0.85 | SYK (0.59) | SYKJAK2ZAP70LYNRET | |
| SCHEMBL1056762 | 0.84 | SYK (0.58) | SYKJAK2ZAP70LYNRET | |
| SCHEMBL1057690 | 0.83 | SYK (0.65) | SYKJAK2ZAP70LYNRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009099801-A1 | PYRIDO [4, 3-D] PYRIMIDINONE DERIVATIVES AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-13 | — | — | WO | disclosed |