Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.60 |
| ▸ | AURKA | O14965 | 3/20 | 0.55 |
| ▸ | CDK4 | P11802 | 3/20 | 0.55 |
| ▸ | JAK2 | O60674 | 14/20 | 0.53 |
| ▸ | BRD4 | O60885 | 14/20 | 0.53 |
| ▸ | JAK1 | P23458 | 4/20 | 0.53 |
| ▸ | BRD2 | P25440 | 4/20 | 0.53 |
| ▸ | JAK3 | P52333 | 4/20 | 0.53 |
| ▸ | BRD3 | Q15059 | 4/20 | 0.53 |
| ▸ | BRDT | Q58F21 | 4/20 | 0.53 |
| ▸ | STAT6 | P42226 | 1/20 | 0.49 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1657471 | 0.88 | RPS6KA3 (0.60) | RPS6KA3AURKACDK4JAK2BRD4 | |
| SCHEMBL1654963 | 0.88 | RPS6KA3 (0.57) | RPS6KA3AURKACDK4JAK2BRD4 | |
| SCHEMBL1655190 | 0.87 | RPS6KA3 (0.56) | RPS6KA3AURKACDK4JAK2BRD4 | |
| SCHEMBL4287854 | 0.83 | RPS6KA3 (0.54) | RPS6KA3AURKACDK4JAK2BRD4 | |
| SCHEMBL4287871 | 0.83 | RPS6KA3 (0.52) | RPS6KA3AURKACDK4JAK2BRD4 | |
| SCHEMBL13749309 | 0.83 | RPS6KA3 (0.55) | RPS6KA3AURKACDK4JAK2BRD4 | |
| SCHEMBL4287865 | 0.83 | RPS6KA3 (0.53) | RPS6KA3AURKACDK4JAK2BRD4 | |
| SCHEMBL4287678 | 0.82 | RPS6KA3 (0.51) | RPS6KA3AURKACDK4JAK2BRD4 | |
| SCHEMBL4287680 | 0.82 | RPS6KA3 (0.51) | RPS6KA3AURKACDK4JAK2BRD4 | |
| SCHEMBL1655945 | 0.81 | CDK4 (0.60) | RPS6KA3AURKACDK4JAK2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009098236-A1 | PYRROLO [2, 3-D] PYRIDINES AND USE THEREOF AS TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2009-08-13 | — | — | WO | disclosed |