Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 2/20 | 0.45 |
| ▸ | SYK | P43405 | 8/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 6/20 | 0.41 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1060202 | 1.00 | ZAP70 (0.45) | ZAP70SYKJAK1JAK3BTK | |
| SCHEMBL13746494 | 0.92 | ZAP70 (0.45) | ZAP70SYKJAK1JAK3BTK | |
| SCHEMBL1056395 | 0.92 | ZAP70 (0.45) | ZAP70SYKJAK1JAK3BTK | |
| SCHEMBL1057874 | 0.90 | ZAP70 (0.46) | ZAP70SYKJAK1JAK3BTK | |
| SCHEMBL1058458 | 0.88 | JAK2 (0.46) | ZAP70SYKJAK1JAK3BTK | |
| SCHEMBL1057114 | 0.86 | SYK (0.45) | ZAP70SYKJAK1JAK3BTK | |
| SCHEMBL1058717 | 0.86 | ZAP70 (0.46) | ZAP70SYKJAK1JAK3JAK2 | |
| SCHEMBL1057940 | 0.86 | ZAP70 (0.44) | ZAP70SYKJAK1JAK3BTK | |
| SCHEMBL1057174 | 0.85 | ZAP70 (0.62) | ZAP70SYKJAK1JAK3JAK2 | |
| SCHEMBL1053641 | 0.85 | SYK (0.56) | ZAP70SYKJAK1JAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009099801-A1 | PYRIDO [4, 3-D] PYRIMIDINONE DERIVATIVES AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-13 | — | — | WO | disclosed |