Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.56 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | PRCP | P42785 | 11/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13747790 | 1.00 | KCNH2 (0.61) | KCNH2CYP3A4CYP2C9NR1I2ABCB11 | |
| SCHEMBL14479567 | 0.92 | KCNH2 (0.70) | KCNH2CYP3A4CYP2C9NR1I2ABCB11 | |
| SCHEMBL2585261 | 0.92 | KCNH2 (0.70) | KCNH2CYP3A4CYP2C9NR1I2ABCB11 | |
| SCHEMBL2586924 | 0.92 | KCNH2 (0.70) | KCNH2CYP3A4CYP2C9NR1I2ABCB11 | |
| SCHEMBL14479575 | 0.92 | KCNH2 (0.70) | KCNH2CYP3A4CYP2C9NR1I2ABCB11 | |
| SCHEMBL3350513 | 0.90 | KCNH2 (0.67) | KCNH2CYP3A4CYP2C9NR1I2ABCB11 | |
| SCHEMBL3348028 | 0.90 | KCNH2 (0.67) | KCNH2CYP3A4CYP2C9NR1I2ABCB11 | |
| SCHEMBL14136711 | 0.85 | KCNH2 (0.61) | KCNH2CYP3A4CYP2C9NR1I2ABCB11 | |
| SCHEMBL1747247 | 0.85 | KCNH2 (0.63) | KCNH2CYP3A4CYP2C9NR1I2ABCB11 | |
| SCHEMBL14136750 | 0.85 | KCNH2 (0.61) | KCNH2CYP3A4CYP2C9NR1I2ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009102325-A1 | IMIDAZOLYL BIPHENYL IMIDAZOLES AS HEPATITIS C VIRUS INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-08-20 | — | — | WO | disclosed |
| WO-2008021927-A2 | HEPATITIS C VIRUS INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-02-21 | — | — | WO | disclosed |