Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 7/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 6/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.37 |
| ▸ | CDK2 | P24941 | 3/20 | 0.37 |
| ▸ | CDK1 | P06493 | 2/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.37 |
| ▸ | SERPINA3 | P01011 | 1/20 | 0.36 |
| ▸ | HPRT1 | P00492 | 2/20 | 0.35 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.35 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13746945 | 0.92 | CYP2C19 (0.39) | HSP90AB1HSP90AA1CYP2C19POLBCCNE1 | |
| SCHEMBL13746895 | 0.91 | HSP90AA1 (0.38) | HSP90AB1HSP90AA1CYP2C19POLBCCNE1 | |
| SCHEMBL13746666 | 0.91 | CYP2C19 (0.40) | HSP90AB1HSP90AA1CYP2C19POLBCCNE1 | |
| SCHEMBL13747563 | 0.90 | SERPINA3 (0.42) | HSP90AB1HSP90AA1CYP2C19POLBCCNE1 | |
| SCHEMBL13746845 | 0.90 | CYP2C19 (0.39) | CYP2C19POLBCCNE1CDK2CDK1 | |
| SCHEMBL2606972 | 0.86 | POLB (0.45) | HSP90AB1HSP90AA1CYP2C19POLBCCNE1 | |
| SCHEMBL12714851 | 0.86 | CYP2C19 (0.39) | CYP2C19POLBCCNE1CDK2CDK1 | |
| SCHEMBL13747170 | 0.86 | POLB (0.40) | CYP2C19POLBCCNE1CDK2CDK1 | |
| SCHEMBL13747884 | 0.83 | CYP2C19 (0.39) | HSP90AB1HSP90AA1CYP2C19POLBCCNE1 | |
| SCHEMBL13747298 | 0.83 | SERPINA3 (0.41) | CYP2C19POLBCCNE1CDK2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009105513-A2 | NOVEL COMPOUNDS AND METHODS FOR THERAPY | GILEAD SCIENCES, INC. (US) | 2009-08-27 | — | — | WO | disclosed |