Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.60 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.43 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.43 |
| ▸ | NOS3 | P29474 | 3/20 | 0.42 |
| ▸ | NOS1 | P29475 | 3/20 | 0.42 |
| ▸ | NOS2 | P35228 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 2/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KHK | P50053 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | CIT | O14578 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30935767 | 0.78 | DYRK1A (0.63) | DYRK1AMKNK1MKNK2NOS3NOS1 | |
| SCHEMBL4402187 | 0.78 | DYRK1A (0.63) | DYRK1AMKNK1MKNK2NOS3NOS1 | |
| SCHEMBL8319877 | 0.78 | DYRK1A (0.51) | DYRK1AMKNK1MKNK2IKBKETBK1 | |
| Hydrochloric Acid SCHEMBL10461111 | 0.76 | DYRK1A (0.61) | DYRK1AMKNK1MKNK2NOS3NOS1 | |
| SCHEMBL17155080 | 0.76 | DYRK1A (0.51) | DYRK1AMKNK1MKNK2NOS3NOS1 | |
| SCHEMBL13633548 | 0.75 | DYRK1A (0.62) | MAP4K4DYRK1AMKNK1MKNK2NOS3 | |
| SCHEMBL4081141 | 0.75 | DYRK1A (0.49) | DYRK1AMKNK1MKNK2NOS3NOS1 | |
| SCHEMBL10918882 | 0.75 | MAP4K4 (0.50) | MAP4K4DYRK1AKDM4EMAPT | |
| SCHEMBL30337203 | 0.74 | DYRK1A (0.70) | DYRK1AMKNK1MKNK2NOS3NOS1 | |
| SCHEMBL4619570 | 0.73 | MAP4K4 (0.58) | MAP4K4DYRK1AMKNK1MKNK2NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737459-B1 | IMIDAZOPYRIDINE AND IMIDAZOPYRIMIDINE DERIVATIVES AS ANTIBACTERIAL AGENTS | WARNER LAMBERT CO (US) | 2009-08-05 | — | — | EP | disclosed |