Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.72 |
| ▸ | STAT6 | P42226 | 2/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 6/20 | 0.33 |
| ▸ | MMP1 | P03956 | 4/20 | 0.33 |
| ▸ | MMP2 | P08253 | 8/20 | 0.32 |
| ▸ | MMP3 | P08254 | 7/20 | 0.32 |
| ▸ | TNF | P01375 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4370422 | 1.00 | TUBB1 (0.72) | TUBB1STAT6ADAM17MMP1MMP2 | |
| SCHEMBL12202205 | 1.00 | TUBB1 (0.72) | TUBB1STAT6ADAM17MMP1MMP2 | |
| Taltobulin SCHEMBL57122 | 0.94 | TUBB1 (0.81) | TUBB1STAT6ADAM17MMP1MMP2 | |
| Taltobulin SCHEMBL13751415 | 0.94 | TUBB1 (0.81) | TUBB1STAT6ADAM17MMP1MMP2 | |
| Taltobulin SCHEMBL6799555 | 0.94 | TUBB1 (0.81) | TUBB1STAT6ADAM17MMP1MMP2 | |
| Taltobulin SCHEMBL13660106 | 0.94 | TUBB1 (0.81) | TUBB1STAT6ADAM17MMP1MMP2 | |
| Taltobulin SCHEMBL4378011 | 0.94 | TUBB1 (0.81) | TUBB1STAT6ADAM17MMP1MMP2 | |
| Taltobulin SCHEMBL58672 | 0.94 | TUBB1 (0.81) | TUBB1STAT6ADAM17MMP1MMP2 | |
| Taltobulin SCHEMBL13848320 | 0.94 | TUBB1 (0.81) | TUBB1STAT6ADAM17MMP1MMP2 | |
| Taltobulin SCHEMBL58356 | 0.94 | TUBB1 (0.81) | TUBB1STAT6ADAM17MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7579323-B1 | Analogs of hemiasterlin wherein the indole moiety of hemiasterlin has been deleted or replaced demonstrate potent anti-mitotic and cytotoxic activity; may be useful in treatment of colon, breast, lung cancers | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2009-08-25 | — | — | US | disclosed |