Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 10/20 | 0.74 |
| ▸ | HTR2B | P41595 | 9/20 | 0.74 |
| ▸ | HTR2A | P28223 | 8/20 | 0.74 |
| ▸ | PROKR1 | Q8TCW9 | 3/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | HTR1E | P28566 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3131164 | 1.00 | HTR2C (0.74) | HTR2CHTR2BHTR2APROKR1ESR1 | |
| SCHEMBL3134776 | 0.92 | HTR2A (0.67) | HTR2CHTR2BHTR2APROKR1ESR1 | |
| SCHEMBL3134771 | 0.92 | HTR2A (0.67) | HTR2CHTR2BHTR2APROKR1ESR1 | |
| SCHEMBL3136870 | 0.92 | HTR2A (0.67) | HTR2CHTR2BHTR2APROKR1ESR1 | |
| SCHEMBL3137627 | 0.88 | HTR2A (0.61) | HTR2CHTR2BHTR2APROKR1ESR1 | |
| SCHEMBL13268737 | 0.88 | HTR2C (0.56) | HTR2CHTR2BHTR2AESR1SIGMAR1 | |
| SCHEMBL5426076 | 0.85 | HTR2C (1.00) | HTR2CHTR2BHTR2AESR1EPHX2 | |
| SCHEMBL5407337 | 0.83 | HTR2C (0.93) | HTR2CHTR2BHTR2AESR1HTR1A | |
| SCHEMBL5407340 | 0.83 | HTR2C (0.93) | HTR2CHTR2BHTR2AESR1HTR1A | |
| SCHEMBL5413099 | 0.83 | HTR2C (0.95) | HTR2CHTR2BHTR2AESR1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1399445-B1 | SUBSTITUTED PYRROLOQUINOLINES AND PYRIDOQUINOLINES AS SEROTONIN AGONISTS AND ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2009-08-05 | — | — | EP | disclosed |