Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 3/20 | 0.49 |
| ▸ | JAK3 | P52333 | 3/20 | 0.49 |
| ▸ | JAK2 | O60674 | 2/20 | 0.49 |
| ▸ | TYK2 | P29597 | 2/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.44 |
| ▸ | NUAK1 | O60285 | 4/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.43 |
| ▸ | MYLK4 | Q86YV6 | 2/20 | 0.43 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.42 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.39 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.39 |
| ▸ | STAT6 | P42226 | 1/20 | 0.39 |
| ▸ | EIF2AK4 | Q9P2K8 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1655180 | 0.81 | JAK2 (0.52) | JAK1JAK3JAK2TYK2ABL1 | |
| SCHEMBL13756772 | 0.81 | LRRK2 (0.48) | JAK2LRRK2STAT6 | |
| SCHEMBL13756760 | 0.81 | LRRK2 (0.44) | JAK1JAK3JAK2LRRK2IKBKE | |
| SCHEMBL13756854 | 0.81 | STAT6 (0.40) | JAK1JAK3JAK2TYK2CDK4 | |
| SCHEMBL13756717 | 0.78 | PIK3CA (0.38) | JAK1JAK3JAK2TYK2CDK6 | |
| SCHEMBL13756805 | 0.77 | STAT6 (0.47) | CSF1RAURKBLRRK2STAT6 | |
| SCHEMBL13756836 | 0.76 | STAT6 (0.40) | JAK2AURKBLRRK2IKBKETBK1 | |
| SCHEMBL13756783 | 0.75 | STAT6 (0.39) | JAK2CSF1RAURKBLRRK2STAT6 | |
| SCHEMBL13756778 | 0.75 | STAT6 (0.39) | JAK2AURKBSTAT6 | |
| SCHEMBL13756789 | 0.75 | STAT6 (0.42) | JAK3PIK3CDAURKBSTAT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090203688-A1 | HETEROCYCLIC COMPOUNDS | NOVARTIS AG | 2009-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203688-A1 | HETEROCYCLIC COMPOUNDS | ABL1, JAK2, JAK1 | JAK1 3/4885JAK3 16/4885JAK2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.