Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT6 | P42226 | 1/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | CYBB | P04839 | 2/20 | 0.44 |
| ▸ | NOX4 | Q9NPH5 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | NOX5 | Q96PH1 | 1/20 | 0.44 |
| ▸ | NOX3 | Q9HBY0 | 1/20 | 0.44 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13756806 | 0.90 | STAT6 (0.58) | STAT6PIK3CAMAPTEGFRAURKA | |
| SCHEMBL13756773 | 0.86 | EGFR (0.49) | STAT6MAPTALDH1A1LMNAMAPK1 | |
| SCHEMBL13756809 | 0.82 | LRRK2 (0.53) | STAT6PIK3CAMAPTALDH1A1LMNA | |
| SCHEMBL1654970 | 0.79 | RPS6KA3 (0.54) | STAT6AURKAAURKBCSF1R | |
| SCHEMBL24464303 | 0.78 | STAT6 (0.49) | STAT6MAPTEGFRTP53AURKA | |
| SCHEMBL13756805 | 0.77 | STAT6 (0.47) | STAT6EGFRTP53AURKAAURKB | |
| SCHEMBL22931675 | 0.76 | BRD4 (0.55) | STAT6PIK3CAEGFRAURKAAURKB | |
| SCHEMBL13756718 | 0.75 | SYK (0.43) | STAT6MAPTLMNAEGFRAURKA | |
| SCHEMBL270947 | 0.75 | PLK4 (0.57) | EGFRAURKAAURKBAXLPLK4 | |
| SCHEMBL13756771 | 0.75 | IGF1R (0.48) | STAT6MAPTLMNACSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090203688-A1 | HETEROCYCLIC COMPOUNDS | NOVARTIS AG | 2009-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203688-A1 | HETEROCYCLIC COMPOUNDS | ABL1, JAK2, JAK1 | STAT6 601/4885PIK3CA 211/4885MAPT 2007/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.