Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 14/20 | 0.35 |
| ▸ | LMNA | P02545 | 11/20 | 0.35 |
| ▸ | TP53 | P04637 | 8/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13758971 | 0.90 | MAPT (0.36) | MAPTLMNATP53RORCMEN1 | |
| SCHEMBL423915 | 0.80 | MAPT (0.39) | MAPTLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL13758986 | 0.77 | MAPT (0.36) | MAPTLMNATP53MEN1KMT2A | |
| SCHEMBL14413185 | 0.77 | MAPT (0.37) | MAPTLMNATP53MEN1KMT2A | |
| SCHEMBL14530422 | 0.75 | CYP3A4 (0.32) | — | |
| SCHEMBL425656 | 0.70 | TYK2 (0.42) | MAPTLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL14413183 | 0.68 | MAPT (0.38) | MAPTLMNATP53MEN1KMT2A | |
| SCHEMBL14413193 | 0.66 | PIKFYVE (0.48) | MAPTLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL14530450 | 0.62 | NPC1 (0.38) | MAPTLMNATP53MEN1KMT2A | |
| SCHEMBL6754541 | 0.58 | MAPT (0.54) | MAPTLMNATP53RORCMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009100406-A2 | TOPICAL FORMULATIONS FOR THE TREATMENT OF PSORIASIS | SYNTA PHARMACEUTICALS CORP. (US) | 2009-08-13 | — | — | WO | disclosed |
| WO-2007100759-A2 | METHOD FOR TREATING COMMON VARIABLE IMMUNODEFICIENCY | SYNTA PHARMACEUTICALS CORP. (US) | 2007-09-07 | — | — | WO | disclosed |
| WO-2007050980-A2 | PROCESS FOR PREPARING MESYLATE SALTS OF IL-12 INHIBITORY COMPOUNDS | SYNTA PHARMACEUTICALS CORP. (US) | 2007-05-03 | — | — | WO | disclosed |