Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | TTK | P33981 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.41 |
| ▸ | IGF1R | P08069 | 2/20 | 0.40 |
| ▸ | LCK | P06239 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | TOP2A | P11388 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL426894 | 0.89 | KIT (0.42) | KITFLT3AURKACCNA2CDK2 | |
| SCHEMBL425313 | 0.86 | KIT (0.45) | KITFLT3AURKACCNA2CDK2 | |
| SCHEMBL13759072 | 0.85 | AURKA (0.42) | KITFLT3AURKACCNA2CDK2 | |
| SCHEMBL14529997 | 0.83 | IGF1R (0.44) | KITFLT3AURKACCNA2CDK2 | |
| SCHEMBL431091 | 0.82 | KIT (0.45) | KITFLT3AURKACCNA2CDK2 | |
| SCHEMBL13759184 | 0.79 | AURKA (0.44) | KITFLT3AURKACCNA2CDK2 | |
| SCHEMBL428542 | 0.79 | AURKA (0.46) | KITFLT3AURKACCNA2CDK2 | |
| SCHEMBL430725 | 0.78 | AURKA (0.43) | KITFLT3AURKACCNA2CDK2 | |
| SCHEMBL12706393 | 0.78 | AURKA (0.43) | AURKASIGMAR1GRM4HSD17B10TOP2A | |
| SCHEMBL425180 | 0.78 | AURKA (0.42) | FLT3AURKACCNA2CDK2TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009100406-A2 | TOPICAL FORMULATIONS FOR THE TREATMENT OF PSORIASIS | SYNTA PHARMACEUTICALS CORP. (US) | 2009-08-13 | — | — | WO | disclosed |