Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIKFYVE | Q9Y2I7 | 2/20 | 0.46 |
| ▸ | FES | P07332 | 1/20 | 0.46 |
| ▸ | FER | P16591 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | FRK | P42685 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 10/20 | 0.42 |
| ▸ | LMNA | P02545 | 7/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | XBP1 | P17861 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13759169 | 0.85 | PIKFYVE (0.43) | PIKFYVEFESFERTYK2FRK | |
| SCHEMBL14530059 | 0.80 | PIKFYVE (0.59) | PIKFYVEFESFERTYK2FRK | |
| SCHEMBL13759367 | 0.78 | FES (0.37) | PIKFYVEFESFERTYK2FRK | |
| SCHEMBL14530772 | 0.77 | PIKFYVE (0.50) | PIKFYVEFESFERTYK2FRK | |
| SCHEMBL14530776 | 0.75 | PIKFYVE (0.51) | PIKFYVEFESFERTYK2FRK | |
| SCHEMBL13759376 | 0.75 | TYK2 (0.69) | PIKFYVEFESFERTYK2FRK | |
| SCHEMBL425602 | 0.75 | PIKFYVE (0.50) | PIKFYVEFESFERTYK2FRK | |
| SCHEMBL425601 | 0.75 | PIKFYVE (0.50) | PIKFYVEFESFERTYK2FRK | |
| SCHEMBL429146 | 0.74 | PIKFYVE (0.47) | PIKFYVEFESFERTYK2FRK | |
| SCHEMBL429145 | 0.74 | PIKFYVE (0.47) | PIKFYVEFESFERTYK2FRK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009100406-A2 | TOPICAL FORMULATIONS FOR THE TREATMENT OF PSORIASIS | SYNTA PHARMACEUTICALS CORP. (US) | 2009-08-13 | — | — | WO | disclosed |